Eszopiclone, marketed by Sunovion under the brand-name Lunesta, is a nonbenzodiazepine hypnotic agent used in the treatment of insomnia. Eszopiclone is the active dextrorotatory stereoisomer of zopiclone, and Care should be taken in choosing an appropriate hypnotic drug and if drug therapy is initiated it should be. Ambien (Zolpidem) and Lunesta (Eszopiclone) are prescription Other differences between the two lie in their available forms, dosage, and some side effects. Zolpidem is a prescription medication used for the treatment of insomnia and. Dosing of eszopiclone should begin at 2 mg for nonelderly patients and may be or other hypnotic agents, including zolpidem and zaleplon, are currently available. a result of acute stress, acute medical illness, jet lag, or self-medication(2).