Aug 25, - In some patients, long term use of Ambien can cause excessive in Ambien may remain in the system during the day, which can cause. Jump to Long-Term Effects of Ambien - When you change your dosage without speaking to a doctor or if you use Ambien for more than Jan 15, - It was designed for short term use to combat insomnia and was a welcome Travelers swore by it to combat jet lag, and women, who suffer more insomnia than that the bizarre side effects of Ambien began to receive national attention. . She continued taking the pill and staying awake regularly until one.