Alprazolam overdoses cause excess central nervous system CNS depression and may include one or more of the following symptoms: [36]. GABA A receptor positive modulators. When you take Xanax with grapefruit or grapefruit juice, the amount of alprazolam in your blood may increase and boost side effects like drowsiness, dizziness and confusion. Conversely, there are reports of withdrawal from carbamazepine and clonidine with symptoms similar to those seen in alprazolam withdrawal, including psychosis Adler et al. Giving alprazolam, as compared to lorazepam, has been demonstrated to elicit a statistically significant increase in extracellular dopamine D1 and D2 concentrations in the striatum. A reasonable guideline Pecknold et al. Xanax: How it Works and a Serious Warning.
Alprazolam, sold under the trade name Xanax, among others, is a short-acting benzodiazepine. Common side effects include sleepiness, depression, headaches, feeling tired, dry mouth, and memory problems. Alprazolam was patented in and approved for medical use in the United States in Alprazolam is mostly used in short term management of anxiety disorders, panic disorders, and nausea due to chemotherapy. Alprazolam is effective in the relief of moderate to severe anxiety and panic attacks. Alprazolam is no longer recommended in Australia for the treatment of panic disorder due to concerns regarding tolerance, dependence, and abuse. However, people with panic disorder have been treated on an open basis for up to 8 months without apparent loss of benefit. In the United States, alprazolam is FDA-approved for the treatment of panic disorder with or without agoraphobia.
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Alprazolam is one of the most widely prescribed benzodiazepines for the treatment of generalized anxiety disorder and panic disorder. Its clinical use has been a point of contention as most addiction specialists consider it to be highly addictive, given its unique psychodynamic properties which limit its clinical usefulness, whereas many primary care physicians continue to prescribe it for longer periods than recommended. Alprazolam is not only the most commonly prescribed benzodiazepine, but it is the most commonly prescribed psychotropic medication in the United States, accounting for more than 48 million prescriptions dispensed in Grohol, This persists despite the fact that many prescribers consider alprazolam to have high misuse liability and it is shown to result in a more severe withdrawal syndrome than other benzodiazepines, even when tapered according to manufacturer guidelines Browne and Hauge, ; Kantor,