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Also known as the Seville orange or the marmalade orange, it is widely cultivated in Mediterranean regions. Its fruit is too bitter to eat, so it is used mainly for making marmalade and as an essential oil for use in perfumes and as a flavouring agent in foods and beverages. In recent years, bitter orange has also become very popular in weight- loss supplements. Ephedra contains ephedrine, which is a known stimulant and also available as a pharmaceutical. Ephedra had been available as a food supplement, leading to widespread use by those seeking to lose weight or improve sports performance. Ephedra is a prescription-only product in Ireland. Within a few months of the ban, about one-third of all herbal weight-loss products contained bitter orange, usually in combination with high doses of caffeine. Bitter orange contains synephrine, which is closely related to ephedrine. However, synephrine exists as a number of isomers, which are very similar compounds.
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