Aug 14, - Find & Review But these drugs may cause you to feel sleepy during the day and can Don't take Lunesta unless you are able to get a full night's sleep as it is now available in an extended release version, Ambien CR. Mar 31, - Lunesta and Ambien are sedative-hypnotics. It's also available in mg and mg extended-release oral tablets, called Ambien CR.?How they work · ?Dosage · ?Side effects · ?Interactions. May 23, - The purpose of this review is to help you choose the right medication. Here we Ambien CR, a time-release pill, is approved for long-term use. Modern hypnotics zolpidem, zaleplon, eszopiclone, and ramelteon are found to.