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Dec 23, - Findings supporting the FDA approval came from 2 randomized, open-label, dose-ranging studies showing bioequivalence between Zolpimist spray and Ambien tablets in young and elderly healthy volunteers. These studies compared the pharmacokinetics and safety of comparable doses of zolpidem. The agency is also warning against driving or other activities requiring mental alertness the day after taking extended-release zolpidem (Ambien CR) at the mg or mg dose because drug levels can remain high enough to impair these activities, a new statement from the FDA notes. This recommendation has been. Medscape - Insomnia dosing for Ambien, Ambien CR (zolpidem), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

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